Bioengineered nanoparticles for siRNA delivery
نویسندگان
چکیده
منابع مشابه
Advances in Lipid Nanoparticles for siRNA Delivery
Technological advances in both siRNA (small interfering RNA) and whole genome sequencing have demonstrated great potential in translating genetic information into siRNA-based drugs to halt the synthesis of most disease-causing proteins. Despite its powerful promises as a drug, siRNA requires a sophisticated delivery vehicle because of its rapid degradation in the circulation, inefficient accumu...
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SUMMARY A smart polymeric nanoparticle (SPN) with matrix metalloproteinase-7 (MMP-7) dependent proximityactivated targeting (PAT) has been designed and tested for targeted intracellular siRNA delivery to MMP-7 overexpressing tissues (i.e., tumor metastases). With this novel PAT-SPN design, a removable PEG corona mitigates cytotoxicity and nonspecific uptake in normal tissues. Exposure to MMP (i...
متن کاملCalcium phosphate nanoparticles-based systems for siRNA delivery
Despite the enormous therapeutic potential of siRNA as a treatment strategy, the delivery is still a problem due to unfavorable biodistribution profiles and poor intracellular bioavailability. Calcium phosphate (CaP) co-precipitate has been used for nearly 40 years for in vitro transfection due to its non-toxic nature and simplicity of preparation. The surface charge of CaP will be tuned into p...
متن کاملCyclic peptide-capped gold nanoparticles for enhanced siRNA delivery.
Previously, we have reported the synthesis of a homochiral l-cyclic peptide [WR]5 and its use for delivery of anti-HIV drugs and biomolecules. A physical mixture of HAuCl4 and the peptide generated peptide-capped gold nanoparticles. Here, [WR]5 and [WR]5-AuNPs were tested for their efficiency to deliver a small interfering RNA molecule (siRNA) in human cervix adenocarcinoma (HeLa) cells. Flow c...
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Developing vehicles for the delivery of therapeutic molecules, like siRNA, is an area of active research. Nanoparticles composed of bovine serum albumin, stabilized via the adsorption of poly-L-lysine (PLL), have been shown to be potentially inert drug-delivery vehicles. With the primary goal of reducing nonspecific protein adsorption, the effect of using comb-type structures of poly(ethylene g...
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ژورنال
عنوان ژورنال: WIREs Nanomedicine and Nanobiotechnology
سال: 2013
ISSN: 1939-5116,1939-0041
DOI: 10.1002/wnan.1233